The process destroys all pathogens listed as index organisms by the State and Territorial Association on Alternative Treatment Technologies (see STAATT I [April 1994] and STAATT II [December 1998] reports) and to be recommended in the new STAATT III Guidelines . The STAATT guidelines call for a system to be able to prove efficacy in the destruction of infectious agents by producing a 6 log10 reduction in vegetative infectious agents and a 4 log10 reduction in spore-forming agents. While each state has its own regulations for approving alternative treatment technologies for regulated medical waste, most of them are derived from or equivalent to the STAATT guidelines.
In the case of one category of disease agents - prions (which are proteins that do not consist of living cells) - the alkaline hydrolysis process has been specifically approved in EU legislation for the treatment of Mad Cow disease and other "Category 1" (TSE transmissible spongiform encephalopathy) wastes, in addition to approval for use with Categories 2 and 3 wastes in Europe.
The same process has been used for years for prion waste as laboratory waste decontamination systems for USDA laboratories and has been cited as an acceptable method of prion waste treatment in USDA and EPA regulations. Recently the US EPA determined that prions were to be treated as "pests" under the Federal Insecticide Fungicide and Rodenticide Act (FIFRA); our systems are registered under FIFRA.